Objective The worldwide spread of antibiotic-resistant microorganisms can be viewed as an ecological consequence of the systematic use of antimicrobial agents. Resistant bacteria prevail in healthcare environments where antibiotic selective pressure is intensive. Novel therapeutic approaches are urgently required to deliver the well-documented existing drugs in an optimized fashion to: i) protect them toward degradation; ii) increase their bioavailability; iii) reduce toxic side effects; iv) increase patient compliance and iv) reduce treatment duration and related costs. In this sense, nanocarriers based on cyclodextrins (CDs) are particularly appealing for the delivery of antibiotics. This approach is of main interest for tuberculosis (TB), infections related to Salmonella Typhimurium, Staphyloccocus aureus and for species most frequently implicated in hospital infections such as enteric gram-negative rods. We will design and characterize CD-based nanocarriers, test their ability to encapsulate drugs, study their efficacy in vitro on bacteria and infected cells. The best formulation will be tested in vivo and scaled up. The objectives of the CycloN Hit project are to take full advantage of nanotechnology and of the high level interdisciplinary expertise of the partners to efficiently encapsulate and protect antibiotics in nanocarriers to combat resistant bacteria, and study the mechanisms in biological systems using state-of-the art techniques. This will be accomplished through a strong and demanding training program for 11 Early Stage and 5 young Experienced Researchers which will gather interdisciplinary expertise of 11 Full partners and 6 Associated partners, of which 7 are SMEs. Using the most recent advances in the nanomedicine field, the final goal of the CycloN Hit project is to bring to the preclinical studies an antibiotic formulation for the treatment of TB and more tailored alternative therapeutic approaches for other resistant microorganisms. Fields of science medical and health scienceshealth sciencespublic healthepidemiologyepidemics prevention Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2013-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS EU contribution € 1 259 170,00 Address RUE MICHEL ANGE 3 75794 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Véronique Debisschop (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Greece EU contribution € 366 969,24 Address END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET 15341 Agia Paraskevi See on map Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Research Organisations Administrative Contact Euripides Papadopoulos (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE CASTILLA - LA MANCHA Spain EU contribution € 234 931,62 Address CALLE ALTAGRACIA 50 13071 Ciudad Real See on map Region Centro (ES) Castilla-La Mancha Ciudad Real Activity type Higher or Secondary Education Establishments Administrative Contact Maria Llanos Carrión Varela (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE ALMERIA Spain EU contribution € 234 931,62 Address CARRETERA SACRAMENTO CANADA 04120 Almeria See on map Region Sur Andalucía Almería Activity type Higher or Secondary Education Establishments Administrative Contact Antonio Miguel Posadas Chinchilla (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI CATANIA Italy EU contribution € 382 894,98 Address PIAZZA UNIVERSITA 2 95131 Catania See on map Region Isole Sicilia Catania Activity type Higher or Secondary Education Establishments Administrative Contact Annamaria Resi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 249 087,96 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Ilse Gert Julia Manet (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HASKOLI ISLANDS Iceland EU contribution € 230 637,00 Address SAEMUNDARGOTU 2 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Higher or Secondary Education Establishments Administrative Contact Thorsteinn Loftsson (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELLENIC PASTEUR INSTITUTE Greece EU contribution € 230 318,88 Address Vassilissis Sofias Avenue 127 11521 Athens See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Vivi Miriagou (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GOETEBORGS UNIVERSITET Sweden EU contribution € 268 175,16 Address VASAPARKEN 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Annika Bergman (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CYCLOLAB CIKLODEXTRIN KUTATO-FEJLESZTO KFT Hungary EU contribution € 205 505,52 Address ILLATOS UT 7 1097 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eva Fenyvesi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NANOLOGICA AB Sweden EU contribution € 232 272,04 Address DROTTNING KRISTINAS VAG 45 114 28 Stockholm See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Roberto Hanoi Labrador (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data